The HLA System and Primary Open-Angle Glaucoma

The HLA system and primary open-angle glaucoma.

Primary open-angle glaucoma

 Primary open-angle glaucoma (POAG) is an idiopathic disorder in which the resistance to outflow through the trabecular meshwork gradually increases and the intraocular pressure (IOP) rises, causing irreversible damage to the optic nerve  POAG is the second most common cause of vision loss in the U.S.  Usually asymptomatic until advanced visual field loss has occurred; less than 50% of those...

primary open-angle glaucoma risk factors

purpose: the objective of this study was to identify possible risk factors associated with primary open-angle glaucoma (poag). methods: a case-control study included patients seen at rasoul-akram hospital ophthalmology clinic. cases were consecutive patients with confirmed unilateral or bilateral poag presented during the study period. controls were a random sample of all other patients aged 30...

The genetics of primary open angle glaucoma.

The advent of the discipline of molecular genetics over the past decade has led to a dramatic growth in our understanding of the genetics of a myriad of diseases. Ophthalmology has benefited greatly from this new technology, with significant advances in our knowledge about conditions as varied as aniridia and retinitis pigmentosa. 2 Our understanding of the genetics of primary open angle glauco...

Association between p53 Codon 72 (Arg72Pro) Polymorphism and Primary Open-Angle Glaucoma in Iranian Patients

Background: Glaucomatous neuropathy is a type of cell death due to apoptosis. The p53 gene is one of the regulatory genes of apoptosis. Recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (POAG) has been studied in some ethnic groups. This study is the first association analysis of POAG and p53 codon 72 polymorphism in Iranian patients...